Proteomic Analysis of The Extracellular Matrix – From Wound Healing to Biomaterials

The extracellular matrix (ECM) provides structural scaffolding and mediates signaling in the extracellular space. The protein component is resistant to chaotrope extraction, making proteomic characterization challenging. We have developed optimized protocols for extraction of ECM that have been refined using samples from many systems, allowing for molecular-scale assessment of ECM proteome composition and architecture. We currently use these methods with the help of collaborators to assess ECM remodeling in wound healing, anti-aging models, tumor progression and regenerative medicine applications.

Join our QBE seminar series with guest speaker, Dr. Kirk C. Hansen, Associate Professor of the Trauma Research Center with the University of Colorado’s Anschutz Medical Campus.  Kirk will discuss the methods used and common features found in wound healing and disease processes.

To read more about Dr. Hansen and his bio, click here.