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QBE Seminar: ‘Strategies for Electromechanical DNA Biosensing of Biological and Environmental Sensing’
February 21 @ 1:00 pm - February 26 @ 2:00 pmFree
ABSTRACT: In this seminar, I will present strategies that my group has employed to adapt biosensors to sensitively detect a variety of biological and environmental targets. As they are inexpensive, rapid, and function in complex media, there is considerable interest in moving these biosensors from the lab bench to applied fields, such as medical, environmental, and food safety diagnostics. Our group has specifically developed biosensors to detect potential biological warfare agents, specifically botulism and ricin, environmental contamination by soluble uranium, and pathogenic mycobacteria responsible for lung disease. I will discuss biosensor design strategy with a focus on predicting conformational shifts between alternative folding states in oligonucleotides to control sensitivity and signaling.
BIO: Andrew J. Bonham is a professor of Biochemistry and a chair of Biochemistry and Chemistry Department at the Metropolitan State University of Denver. He is Denver-native who obtained his PhD developing tools to investigate novel protein-DNA interactions, and is teaching biochemistry, raising scientific awareness, and continuing research. H. Prior to being at Metro State, he earned his PhD in Biochemistry and Molecular Biology at the University of California Santa Barbra.